Monitoring the Agung (Indonesia) ash plume of November 2017 by means of infrared Himawari 8 data

The Agung volcano (Bali; Indonesia) erupted in later November 2017 after several years of quiescence. Because of ash emissions, hundreds of flights were cancelled, causing an important air traffic disruption in Indonesia. We investigate those ash emissions from space by applying the RSTASH algorithm for the first time to Himawari-8 data and using an ad hoc implementation scheme to reduce the time of the elaboration processes. Himawari-8 is a new generation Japanese geostationary meteorological satellite, whose AHI (Advanced Himawari Imager) sensor offers improved features, in terms of spectral, spatial and temporal resolution, in comparison with the previous imagers of the MTSAT (Multi-Functional Transport Satellite) series. Those features should guarantee further improvements in monitoring rapidly evolving weather/environmental phenomena. Results of this work show that RSTASH was capable of successfully detecting and tracking the Agung ash plume, despite some limitations (e.g., underestimation of ash coverage under certain conditions; generation of residual artefacts). Moreover, estimates of ash cloud-top height indicate that the monitored plume extended up to an altitude of about 9.3 km above sea level during the period 25 November at 21:10 UTC-26 November at 00:50 UTC. The study demonstrates that RSTASH may give a useful contribution for the operational monitoring of ash clouds over East Asia and the Western Pacific region, well exploiting the 10 min temporal resolution and the spectral features of the Himawari-8 data

Chemical composition, antibacterial and antioxidant activities of essential oils from flowers, leaves and aerial parts of Tunisian Dittrichia Viscosa

The objective of this work was to determine the chemical composition, the antioxidant and antibacterial activities of the essential oils (EOs) extracted by hydrodistillation from different organs of the D. viscosa: flowers, leaves and aerial parts. The main compounds identified by GC/MS are oxygenated sesquiterpenes. Among these compounds, (E)-nerolidol (40.7%) is the most abundant constituent of flowers’ essential oil while caryophyllene oxide (9.9%), isolongifolan-7-α-ol (10.3%) and α -eudesmol (9.1%) are the major constituents of the leaves’ essential oil. The presence of these compounds in the aerial parts’ essential oil is solely due to those of the flowers and leaves that constitute these aerial parts. The volatile extracts showed antioxidant effects with IC50 values ranging between 9.25 and 9.75 mg.mL−1. On the other hand, EOs showed antibacterial effects on both Gram-positive and Gram-negative bacteria. The highest activity was obtained with flowers’ essential oil against Enterococcus faecalis and Escherichia coli

Burnout, well-being and defensive medical practice among obstetricians and gynaecologists in the UK: cross-sectional survey study

Objectives: To determine the prevalence of burnout in doctors practising obstetrics and gynaecology, and assess the association with defensive medical practice and self-reported wellbeing. Design: Nationwide online cross-sectional survey study; December 2017-March 2018. Setting: Hospitals in the United Kingdom Participants: 5661 practising Obstetrics and Gynaecology consultants, specialty and associate specialist doctors and trainees registered with the Royal College of Obstetricians and Gynaecologists Primary and Secondary Outcome Measures: Prevalence of burnout using the Maslach Burnout Inventory and defensive medical practice (avoiding cases or procedures, overprescribing, over-referral) using a 12-item questionnaire. The odds ratios of burnout with defensive medical practice and self-reported wellbeing. Results: 3102/5661 doctors (55%) completed the survey. 3073/3102 (99%) met the inclusion criteria (1462 consultants, 1357 trainees and 254 specialty and associate specialist doctors). 1116/3073 (36%) doctors met the burnout criteria, with levels highest amongst trainees (580/1357 [43%]). 258/1116 (23%) doctors with burnout reported increased defensive practice compared to 142/1957 (7%) without (adjusted odds ratio 4.35, 95% CI 3.46 to 5.49). Odds ratios of burnout with wellbeing items varied between 1.38 and 6.37, and were highest for anxiety (3.59, 95% CI 3.07 to 4.21), depression (4.05, 95% CI 3.26 to 5.04), and suicidal thoughts (6.37, 95% CI 95% CI 3.95 to 10.7). In multivariable logistic regression, being of younger age, white or ‘other’ ethnicity, and graduating with a medical degree from the UK or Ireland had the strongest associations with burnout. Conclusions: High levels of burnout were observed in obstetricians and gynaecologists and particularly amongst trainees. Burnout was associated with both increased defensive medical practice and worse doctor wellbeing. These findings have implications for the wellbeing and retention of doctors as well as the quality of patient care, and may help to inform the content of future interventions aimed at preventing burnout and improving patient safety

Biological Assays and Chemical Composition of Volatile Oils of Bupleurum fruticosum L. (Apiaceae)

The composition of supercritical CO 2 extracts and essential oils obtained by hydrodistillation of Bupleurum fruticosum L., growing spontaneously in Italy and Portugal, and its antifungal activity is reported. The collected extracts were analyzed by GC-FID and GC-MS methods. The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida albicans, C. tropicalis, C. krusei, C. guillermondii, C. parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, T. mentagrophytes, Microsporum canis, M. gypseum, Epidermophyton floccosum, Aspergillus niger, A. fumigatus and A. flavus

Validation of ash/dust detections from SEVIRI data using ACTRIS/EARLINET ground-based LIDAR measurements

Twotailored configurations of the Robust Satellite Technique (RST) multi-temporal approach, for airborne volcanic ash and desert dust detection, have been tested in the framework of the European Natural Airborne Disaster Information and Coordination System for Aviation (EUNADICS-AV) project. The two algorithms, running on Spinning Enhanced Visible Infra-Red Imager (SEVIRI) data, were previously assessed over wide areas by comparison with independent satellite-based aerosol products. In this study, we present results of a first validation analysis of the above mentioned satellite-based ash/dust products using independent, ground-based observations coming from the European Aerosol Research Lidar Network (EARLINET). The aim is to assess the capabilities of RST-based ash/dust products in providing useful information even at local scale and to verify their applicability as a "trigger" to timely activate EARLINET measurements during airborne hazards. The intense Saharan dust event of May 18-23 2008-which affected both the Mediterranean Basin and Continental Europe-and the strong explosive eruptions of Eyjafjallajökull (Iceland) volcano of April-May 2010, were analyzed as test cases. Our results show that both RST-based algorithms were capable of providing reliable information about the investigated phenomena at specific sites of interest, successfully detecting airborne ash/dust in different geographic regions using both nighttime and daytime SEVIRI data. However, the validation analysis also demonstrates that ash/dust layers remain undetected by satellite in the presence of overlying meteorological clouds and when they are tenuous (i.e., with an integrated backscatter coefficient less than ~0.001 sr-1 and with aerosol backscatter coefficient less than ~1 × 10-6 m-1sr-1). This preliminary analysis confirms that the continuity of satellite-based observations can be used to timely "trigger" ground-based LIDAR measurements in case of airborne hazard events. Finally, this work confirms that advanced satellite-based detection schemes may provide a relevant contribution to the monitoring of ash/dust phenomena and that the synergistic use of (satellite-based) large scale, continuous and timely records with (ground-based) accurate and quantitative measurements may represent an added value, especially in operational scenarios

Object-oriented Programming Laws for Annotated Java Programs

Object-oriented programming laws have been proposed in the context of languages that are not combined with a behavioral interface specification language (BISL). The strong dependence between source-code and interface specifications may cause a number of difficulties when transforming programs. In this paper we introduce a set of programming laws for object-oriented languages like Java combined with the Java Modeling Language (JML). The set of laws deals with object-oriented features taking into account their specifications. Some laws deal only with features of the specification language. These laws constitute a set of small transformations for the development of more elaborate ones like refactorings

Tropospheric and ionospheric anomalies induced by volcanic and saharan dust events as part of geosphere interaction phenomena

In this work, we assessed the possible relation of ionospheric perturbations observed by Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions (DEMETER), Global Positioning System total electron content (GPS TEC), National Oceanic and Atmospheric Administration (NOAA)-derived outgoing longwave-Earth radiation (OLR), and atmospheric chemical potential (ACP) measurements, with volcanic and Saharan dust events identified by ground and satellite-based medium infrared/thermal infrared (MIR/TIR) observations. The results indicated that the Mt. Etna (Italy) volcanic activity of 2006 was probably responsible for the ionospheric perturbations revealed by DEMETER on 4 November and 6 December and by GPS TEC observations on 4 November and 12 December. This activity also affected the OLR (on 26 October; 6 and 23 November; and 2, 6, and 14 December) and ACP (on 31 October-1 November) analyses. Similarly, two massive Saharan dust episodes, detected by Robust Satellite Techniques (RST) using Spinning Enhanced Visible and Infrared Imager (SEVIRI) optical data, probably caused the ionospheric anomalies recorded, based on DEMETER and GPS TEC observations, over the Mediterranean basin in May 2008. The study confirmed the perturbing effects of volcanic and dust events on tropospheric and ionospheric parameters. Further, it demonstrated the advantages of using independent satellite observations to investigate atmospheric phenomena, which may not always be well documented. The impact of this increased detection capacity in reducing false positives, in the framework of a short-term seismic hazard forecast based on the study of ionospheric and tropospheric anomalies, is also addressed

European real world trans-catheter aortic valve implantation:systematic review and meta-analysis of European national registries

OBJECTIVE: Transcatheter aortic valve implantation (TAVI) has been adopted rapidly in Europe. TAVI national registries can augment understanding of technologies and represent real-world experience, providing further clinical insights. We undertook a meta-analysis of published European national TAVI registries to assess current results following TAVI in Europe. METHODS: Electronic databases were searched. The review focused on the comparison of the following TAVI strategies: transfemoral (TF) and transapical (TA) SAPIEN and CoreValve implantation. Individual event rates for outcomes of interest were pooled using a mixed effect model. RESULTS: Seven European national TAVI registries (UK, Swiss, Belgium, Italy, Spain, France, Germany) were identified, including a total of 9786 patients who received TF-SAPIEN (n = 2885), TA-SAPIEN (n = 2252) and CoreValve (n = 4649) implantation. Pooled incidence of 30-day mortality was 0.08% [95% Confidence Interval (CI): 0.05–0.11], 0.12% [95% CI: 0.07–0.19] and 0.06% [95% CI: 0.03–0.11] for TF-SAPIEN, TA-SAPIEN and CoreValve respectively (test for subgroup difference P = 0.18); there was high heterogeneity across European countries. Pooled incidence of stroke was comparable among the TAVI strategies (test for subgroup difference P = 0.79); the incidence of post-procedural moderate paravalvular leak ≥ 2 (P = 0.9) was similar across groups. CoreValve implantation was associated with an increased risk of pacemaker implantation (0.22 [95% CI: 0.19–0.26]; test for subgroup difference P < 0.0001). The lowest 30-day mortality was associated with TAVI performed in Spain (b coefficient −4.3; P = 0.03), in Italy (b coefficient −2.1; P < 0.0001), in UK (b coefficient −1.95; P = 0.01) and in France (b coefficient −2.8; P = 0.03). The German registry has the highest mortality for every TAVI strategy amongst all other European registries and especially for the TA-SAPIEN group. CONCLUSIONS: Transarterial TAVI approaches were associated with a low early mortality regardless of the type of device used. There was marked heterogeneity among European countries for early mortality